About Nicolin-1
Nicolin-1 (NICN1) is a protein
from Homo sapiens identified by UniProt accession
Q9BSH3, 213 residues long.
MolForge cross-references it against 0 known binders and
89 disease associations.
Target properties
| Protein name | Nicolin-1 |
|---|
| UniProt accession | Q9BSH3 |
|---|
| Gene | NICN1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 213 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (89)
Diseases linked to this target (Open Targets).
- glycine encephalopathy · score 0.56
- Neurodevelopmental delay · score 0.34
- Alzheimer disease · score 0.30
- neurodegenerative disease · score 0.30
- multiple sclerosis · score 0.30
- lysosomal storage disease · score 0.30
- Parkinson disease · score 0.30
- genetic disorder · score 0.16
- Red cell distribution width · score 0.12
- osteoporosis · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BSH3-F1 | alphafold | PREDICTED | 79.71 | — |
Amino-acid sequence (213 residues)
MSRVLVPCHV KGSVALQVGD VRTSQGRPGV LVIDVTFPSV APFELQEITF KNYYTAFLSI RVRQYTSAHT PAKWVTCLRD YCLMPDPHSE EGAQEYVSLF KHQMLCDMAR ISELRLILRQ PSPLWLSFTV EELQIYQQGP KSPSVTFPKW LSHPVPCEQP ALLREGLPDP SRVSSEVQQM WALTEMIRAS HTSARIGRFD VDGCYDLNLL SYT
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