About Protein fem-1 homolog A
Protein fem-1 homolog A (FEM1A) is a protein
from Homo sapiens identified by UniProt accession
Q9BSK4, 669 residues long.
MolForge cross-references it against 0 known binders and
109 disease associations.
Target properties
| Protein name | Protein fem-1 homolog A |
|---|
| UniProt accession | Q9BSK4 |
|---|
| Gene | FEM1A |
|---|
| Organism | Homo sapiens |
|---|
| Length | 669 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (109)
Diseases linked to this target (Open Targets).
- body height · score 0.20
- appendicular lean mass · score 0.10
- colitis · score 0.07
- Lynch syndrome · score 0.07
- inflammatory bowel disease · score 0.07
- hereditary mixed polyposis syndrome · score 0.06
- Autosomal recessive early-onset inflammatory bowel disease · score 0.06
- familial adenomatous polyposis 2 · score 0.06
- Hirschsprung disease · score 0.06
- Constitutional mismatch repair deficiency syndrome · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BSK4-F1 | alphafold | PREDICTED | 88.71 | — |
Amino-acid sequence (669 residues)
MDLRTAVYNA ARDGKLQLLQ KLLSGRSREE LDELTGEVAG GGTPLLIAAR YGHLDVVEYL VDRCGASVEA GGSVHFDGET IEGAPPLWAA SAAGHLDVVR SLLRRGASVN RTTRTNSTPL RAACFDGHLE VVRYLVGEHQ ADLEVANRHG HTCLMISCYK GHREIARYLL EQGAQVNRRS AKGNTALHDC AESGSLEILQ LLLGCKARME RDGYGMTPLL AASVTGHTNI VEYLIQEQPG QEQVAGGEAQ PGLPQEDPST SQGCAQPQGA PCCSSSPEEP LNGESYESCC PTSREAAVEA LELLGATYVD KKRDLLGALK HWRRAMELRH QGGEYLPKPE PPQLVLAYDY SREVNTTEEL EALITDPDEM RMQALLIRER ILGPSHPDTS YYIRYRGAVY ADSGNFERCI RLWKYALDMQ QSNLEPLSPM TASSFLSFAE LFSYVLQDRA AKGSLGTQIG FADLMGVLTK GVREVERALQ LPREPGDSAQ FTKALAIILH LLYLLEKVEC TPSQEHLKHQ TVYRLLKCAP RGKNGFTPLH MAVDKDTTNV GRYPVGRFPS LHVVKVLLDC GADPDSRDFD NNTPLHIAAQ NNCPAIMNAL IEAGAHMDAT NAFKKTAYEL LDEKLLARGT MQPFNYVTLQ CLAARALDKN KIPYKGFIPE DLEAFIELH
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