About Ubiquitin-associated domain-containing protein 1
Ubiquitin-associated domain-containing protein 1 (UBAC1) is a protein
from Homo sapiens identified by UniProt accession
Q9BSL1, 405 residues long.
MolForge cross-references it against 0 known binders and
81 disease associations.
Target properties
| Protein name | Ubiquitin-associated domain-containing protein 1 |
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| UniProt accession | Q9BSL1 |
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| Gene | UBAC1 |
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| Organism | Homo sapiens |
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| Length | 405 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (81)
Diseases linked to this target (Open Targets).
- hemoglobin E-beta-thalassemia syndrome · score 0.06
- primary familial polycythemia due to EPO receptor mutation · score 0.05
- hereditary persistence of fetal hemoglobin-sickle cell disease syndrome · score 0.05
- alpha-thalassemia-myelodysplastic syndrome · score 0.05
- hemoglobin D disease · score 0.05
- Blackfan-Diamond anemia · score 0.05
- dehydrated hereditary stomatocytosis · score 0.05
- beta-thalassemia-X-linked thrombocytopenia syndrome · score 0.05
- Adult-onset autosomal recessive sideroblastic anemia · score 0.05
- Rh deficiency syndrome · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BSL1-F1 | alphafold | PREDICTED | 74.81 | — |
Amino-acid sequence (405 residues)
MFVQEEKIFA GKVLRLHICA SDGAEWLEEA TEDTSVEKLK ERCLKHCAHG SLEDPKSITH HKLIHAASER VLSDARTILE ENIQDQDVLL LIKKRAPSPL PKMADVSAEE KKKQDQKAPD KEAILRATAN LPSYNMDRAA VQTNMRDFQT ELRKILVSLI EVAQKLLALN PDAVELFKKA NAMLDEDEDE RVDEAALRQL TEMGFPENRA TKALQLNHMS VPQAMEWLIE HAEDPTIDTP LPGQAPPEAE GATAAASEAA AGASATDEEA RDELTEIFKK IRRKREFRAD ARAVISLMEM GFDEKEVIDA LRVNNNQQNA ACEWLLGDRK PSPEELDKGI DPDSPLFQAI LDNPVVQLGL TNPKTLLAFE DMLENPLNST QWMNDPETGP VMLQISRIFQ TLNRT
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