RNA demethylase ALKBH7, mitochondrial (ALKBH7)

About RNA demethylase ALKBH7, mitochondrial

RNA demethylase ALKBH7, mitochondrial (ALKBH7) is a protein from Homo sapiens identified by UniProt accession Q9BT30, 221 residues long. MolForge cross-references it against 0 known binders and 46 disease associations.

Target properties

Protein name	RNA demethylase ALKBH7, mitochondrial
UniProt accession	Q9BT30
Gene	ALKBH7
Organism	Homo sapiens
Length	221 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (46)

Diseases linked to this target (Open Targets).

cancer · score 0.08
glioblastoma · score 0.07
neoplasm · score 0.05
hyperinsulinism due to HNF1A deficiency · score 0.04
obesity due to melanocortin 4 receptor deficiency · score 0.04
autosomal dominant hyperinsulinism due to SUR1 deficiency · score 0.04
autosomal dominant hyperinsulinism due to Kir6.2 deficiency · score 0.04
hyperinsulinism due to UCP2 deficiency · score 0.04
familial partial lipodystrophy, Dunnigan type · score 0.03
obesity due to prohormone convertase I deficiency · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BT30-F1	alphafold	PREDICTED	89.15	—

Amino-acid sequence (221 residues)

MAGTGLLALR TLPGPSWVRG SGPSVLSRLQ DAAVVRPGFL STAEEETLSR ELEPELRRRR YEYDHWDAAI HGFRETEKSR WSEASRAILQ RVQAAAFGPG QTLLSSVHVL DLEARGYIKP HVDSIKFCGA TIAGLSLLSP SVMRLVHTQE PGEWLELLLE PGSLYILRGS ARYDFSHEIL RDEESFFGER RIPRGRRISV ICRSLPEGMG PGESGQPPPA C

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards