NADH dehydrogenase [ubiquinone] 1 alpha subcomplex…

About NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 (NDUFAF3) is a protein from Homo sapiens identified by UniProt accession Q9BU61, 184 residues long. MolForge cross-references it against 0 known binders and 233 disease associations.

Target properties

Protein name	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3
UniProt accession	Q9BU61
Gene	NDUFAF3
Organism	Homo sapiens
Length	184 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (233)

Diseases linked to this target (Open Targets).

mitochondrial complex I deficiency · score 0.74
type 2 diabetes mellitus · score 0.61
diabetes mellitus · score 0.61
polycystic ovary syndrome · score 0.60
type 1 diabetes mellitus · score 0.59
gestational diabetes · score 0.58
obesity · score 0.57
prediabetes syndrome · score 0.56
schizophrenia · score 0.55
insulin resistance · score 0.55

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BU61-F1	alphafold	PREDICTED	78.96	—

Amino-acid sequence (184 residues)

MATALALRSL YRARPSLRCP PVELPWAPRR GHRLSPADDE LYQRTRISLL QREAAQAMYI DSYNSRGFMI NGNRVLGPCA LLPHSVVQWN VGSHQDITED SFSLFWLLEP RIEIVVVGTG DRTERLQSQV LQAMRQRGIA VEVQDTPNAC ATFNFLCHEG RVTGAALIPP PGGTSLTSLG QAAQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 (NDUFAF3)