About Mediator of RNA polymerase II transcription subunit 18
Mediator of RNA polymerase II transcription subunit 18 (MED18) is a protein
from Homo sapiens identified by UniProt accession
Q9BUE0, 208 residues long.
MolForge cross-references it against 0 known binders and
18 disease associations.
Target properties
| Protein name | Mediator of RNA polymerase II transcription subunit 18 |
|---|
| UniProt accession | Q9BUE0 |
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| Gene | MED18 |
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| Organism | Homo sapiens |
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| Length | 208 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (18)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- protein measurement · score 0.23
- eosinophil count · score 0.03
- pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 9 · score 0.03
- systolic blood pressure · score 0.02
- infect · score 0.02
- infection · score 0.02
- gonorrhea · score 0.02
- osteosarcoma · score 0.02
- neoplasm · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BUE0-F1 | alphafold | PREDICTED | 89.48 | — |
Amino-acid sequence (208 residues)
MEAPPVTMMP VTGGTINMME YLLQGSVLDH SLESLIHRLR GLCDNMEPET FLDHEMVFLL KGQQASPFVL RARRSMDRAG APWHLRYLGQ PEMGDKNRHA LVRNCVDIAT SENLTDFLME MGFRMDHEFV AKGHLFRKGI MKIMVYKIFR ILVPGNTDST EALSLSYLVE LSVVAPAGQD MVSDDMKNFA EQLKPLVHLE KIDPKRLM
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