Protein crumbs homolog 3 (CRB3)

About Protein crumbs homolog 3

Protein crumbs homolog 3 (CRB3) is a protein from Homo sapiens identified by UniProt accession Q9BUF7, 120 residues long. MolForge cross-references it against 0 known binders and 63 disease associations.

Target properties

Protein name	Protein crumbs homolog 3
UniProt accession	Q9BUF7
Gene	CRB3
Organism	Homo sapiens
Length	120 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (63)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.28
breast adenocarcinoma · score 0.25
endometrial cancer · score 0.23
head and neck squamous cell carcinoma · score 0.15
monocyte count · score 0.09
cyst · score 0.08
oral squamous cell carcinoma · score 0.07
triple-negative breast cancer · score 0.06
neoplasm · score 0.05
Neonatal acute respiratory distress with surfactant metabolism deficiency · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BUF7-F1	alphafold	PREDICTED	69.44	—

Amino-acid sequence (120 residues)

MANPGLGLLL ALGLPFLLAR WGRAWGQIQT TSANENSTVL PSSTSSSSDG NLRPEAITAI IVVFSLLAAL LLAVGLALLV RKLREKRQTE GTYRPSSEEQ VGARVPPTPN LKLPPEERLI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards