About GTP-binding protein 2
GTP-binding protein 2 (GTPBP2) is a protein
from Homo sapiens identified by UniProt accession
Q9BX10, 602 residues long.
MolForge cross-references it against 0 known binders and
44 disease associations.
Target properties
| Protein name | GTP-binding protein 2 |
|---|
| UniProt accession | Q9BX10 |
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| Gene | GTPBP2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 602 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (44)
Diseases linked to this target (Open Targets).
- Jaberi-Elahi syndrome · score 0.75
- Intellectual disability · score 0.49
- Seizure · score 0.46
- Global developmental delay · score 0.46
- breast adenocarcinoma · score 0.25
- neurodegenerative disease · score 0.23
- multiple sclerosis · score 0.23
- lysosomal storage disease · score 0.23
- Alzheimer disease · score 0.23
- Parkinson disease · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BX10-F1 | alphafold | PREDICTED | 83.21 | — |
Amino-acid sequence (602 residues)
MDSRVSELFG GCCRPGGGPA VGGTLKARGA GSSSGCGGPK GKKKNGRNRG GKANNPPYLP PEAEDGNIEY KLKLVNPSQY RFEHLVTQMK WRLQEGRGEA VYQIGVEDNG LLVGLAEEEM RASLKTLHRM AEKVGADITV LREREVDYDS DMPRKITEVL VRKVPDNQQF LDLRVAVLGN VDSGKSTLLG VLTQGELDNG RGRARLNLFR HLHEIQSGRT SSISFEILGF NSKGEVVNYS DSRTAEEICE SSSKMITFID LAGHHKYLHT TIFGLTSYCP DCALLLVSAN TGIAGTTREH LGLALALKVP FFIVVSKIDL CAKTTVERTV RQLERVLKQP GCHKVPMLVT SEDDAVTAAQ QFAQSPNVTP IFTLSSVSGE SLDLLKVFLN ILPPLTNSKE QEELMQQLTE FQVDEIYTVP EVGTVVGGTL SSGICREGDQ LVVGPTDDGC FLELRVCSIQ RNRSACRVLR AGQAATLALG DFDRALLRKG MVMVSPEMNP TICSVFEAEI VLLFHATTFR RGFQVTVHVG NVRQTAVVEK IHAKDKLRTG EKAVVRFRFL KHPEYLKVGA KLLFREGVTK GIGHVTDVQA ITAGEAQANM GF
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