Plasmalemma vesicle-associated protein (PLVAP)

About Plasmalemma vesicle-associated protein

Plasmalemma vesicle-associated protein (PLVAP) is a protein from Homo sapiens identified by UniProt accession Q9BX97, 442 residues long. MolForge cross-references it against 0 known binders and 191 disease associations.

Target properties

Protein name	Plasmalemma vesicle-associated protein
UniProt accession	Q9BX97
Gene	PLVAP
Organism	Homo sapiens
Length	442 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (191)

Diseases linked to this target (Open Targets).

Congenital chronic diarrhea with protein-losing enteropathy · score 0.57
blood phosphate measurement · score 0.24
reticulocyte count · score 0.21
reticulocyte measurement · score 0.19
genetic disorder · score 0.19
neoplasm · score 0.10
total cholesterol measurement · score 0.07
hepatocellular carcinoma · score 0.07
low density lipoprotein cholesterol measurement · score 0.05
congenital secretory chloride diarrhea 1 · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BX97-F1	alphafold	PREDICTED	81.67	—

Amino-acid sequence (442 residues)

MGLAMEHGGS YARAGGSSRG CWYYLRYFFL FVSLIQFLII LGLVLFMVYG NVHVSTESNL QATERRAEGL YSQLLGLTAS QSNLTKELNF TTRAKDAIMQ MWLNARRDLD RINASFRQCQ GDRVIYTNNQ RYMAAIILSE KQCRDQFKDM NKSCDALLFM LNQKVKTLEV EIAKEKTICT KDKESVLLNK RVAEEQLVEC VKTRELQHQE RQLAKEQLQK VQALCLPLDK DKFEMDLRNL WRDSIIPRSL DNLGYNLYHP LGSELASIRR ACDHMPSLMS SKVEELARSL RADIERVARE NSDLQRQKLE AQQGLRASQE AKQKVEKEAQ AREAKLQAEC SRQTQLALEE KAVLRKERDN LAKELEEKKR EAEQLRMELA IRNSALDTCI KTKSQPMMPV SRPMGPVPNP QPIDPASLEE FKRKILESQR PPAGIPVAPS SG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards