Hydroxycarboxylic acid receptor 1 (HCAR1)

About Hydroxycarboxylic acid receptor 1

Hydroxycarboxylic acid receptor 1 (HCAR1) is a protein from Homo sapiens identified by UniProt accession Q9BXC0, 346 residues long. MolForge cross-references it against 0 known binders and 153 disease associations.

Target properties

Protein name	Hydroxycarboxylic acid receptor 1
UniProt accession	Q9BXC0
Gene	HCAR1
Organism	Homo sapiens
Length	346 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (153)

Diseases linked to this target (Open Targets).

glioblastoma multiforme · score 0.26
thyroid gland adenocarcinoma · score 0.16
high density lipoprotein cholesterol measurement · score 0.16
Oral ulcer · score 0.15
Red cell distribution width · score 0.13
mean corpuscular volume · score 0.12
mean corpuscular hemoglobin concentration · score 0.12
triglyceride measurement · score 0.12
waist-hip ratio · score 0.11
platelet-to-lymphocyte ratio · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BXC0-F1	alphafold	PREDICTED	80.91	—

Amino-acid sequence (346 residues)

MYNGSCCRIE GDTISQVMPP LLIVAFVLGA LGNGVALCGF CFHMKTWKPS TVYLFNLAVA DFLLMICLPF RTDYYLRRRH WAFGDIPCRV GLFTLAMNRA GSIVFLTVVA ADRYFKVVHP HHAVNTISTR VAAGIVCTLW ALVILGTVYL LLENHLCVQE TAVSCESFIM ESANGWHDIM FQLEFFMPLG IILFCSFKIV WSLRRRQQLA RQARMKKATR FIMVVAIVFI TCYLPSVSAR LYFLWTVPSS ACDPSVHGAL HITLSFTYMN SMLDPLVYYF SSPSFPKFYN KLKICSLKPK QPGHSKTQRP EEMPISNLGR RSCISVANSF QSQSDGQWDP HIVEWH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards