Probable G-protein coupled receptor 174 (GPR174)

About Probable G-protein coupled receptor 174

Probable G-protein coupled receptor 174 (GPR174) is a protein from Homo sapiens identified by UniProt accession Q9BXC1, 333 residues long. MolForge cross-references it against 0 known binders and 79 disease associations.

Target properties

Protein name	Probable G-protein coupled receptor 174
UniProt accession	Q9BXC1
Gene	GPR174
Organism	Homo sapiens
Length	333 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (79)

Diseases linked to this target (Open Targets).

rheumatoid arthritis · score 0.36
Sepsis · score 0.09
autoimmune disease · score 0.08
3-hydroxy-1-methylpropylmercapturic acid measurement · score 0.07
C1 inhibitor deficiency · score 0.07
colitis · score 0.06
common variable immunodeficiency · score 0.06
Hashimoto's thyroiditis · score 0.06
pemphigus vulgaris · score 0.06
inborn error of immunity · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BXC1-F1	alphafold	PREDICTED	84.14	—

Amino-acid sequence (333 residues)

MPANYTCTRP DGDNTDFRYF IYAVTYTVIL VPGLIGNILA LWVFYGYMKE TKRAVIFMIN LAIADLLQVL SLPLRIFYYL NHDWPFGPGL CMFCFYLKYV NMYASIYFLV CISVRRFWFL MYPFRFHDCK QKYDLYISIA GWLIICLACV LFPLLRTSDD TSGNRTKCFV DLPTRNVNLA QSVVMMTIGE LIGFVTPLLI VLYCTWKTVL SLQDKYPMAQ DLGEKQKALK MILTCAGVFL ICFAPYHFSF PLDFLVKSNE IKSCLARRVI LIFHSVALCL ASLNSCLDPV IYYFSTNEFR RRLSRQDLHD SIQLHAKSFV SNHTASTMTP ELC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards