About Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase
Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase (B3GNT5) is a protein
from Homo sapiens identified by UniProt accession
Q9BYG0, 378 residues long.
MolForge cross-references it against 0 known binders and
145 disease associations.
Target properties
| Protein name | Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase |
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| UniProt accession | Q9BYG0 |
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| Gene | B3GNT5 |
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| Organism | Homo sapiens |
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| Length | 378 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (145)
Diseases linked to this target (Open Targets).
- PHF-tau measurement · score 0.31
- Hodgkins lymphoma · score 0.07
- classic Hodgkin lymphoma · score 0.07
- Waldenstrom macroglobulinemia · score 0.06
- isolated agammaglobulinemia · score 0.06
- common variable immunodeficiency · score 0.06
- immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia · score 0.06
- immunodeficiency 105 · score 0.06
- combined immunodeficiency with skin granulomas · score 0.06
- glioblastoma multiforme · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BYG0-F1 | alphafold | PREDICTED | 90.85 | — |
Amino-acid sequence (378 residues)
MRMLVSGRRV KKWQLIIQLF ATCFLASLMF FWEPIDNHIV SHMKSYSYRY LINSYDFVND TLSLKHTSAG PRYQYLINHK EKCQAQDVLL LLFVKTAPEN YDRRSGIRRT WGNENYVRSQ LNANIKTLFA LGTPNPLEGE ELQRKLAWED QRYNDIIQQD FVDSFYNLTL KLLMQFSWAN TYCPHAKFLM TADDDIFIHM PNLIEYLQSL EQIGVQDFWI GRVHRGAPPI RDKSSKYYVS YEMYQWPAYP DYTAGAAYVI SGDVAAKVYE ASQTLNSSLY IDDVFMGLCA NKIGIVPQDH VFFSGEGKTP YHPCIYEKMM TSHGHLEDLQ DLWKNATDPK VKTISKGFFG QIYCRLMKII LLCKISYVDT YPCRAAFI
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