Tripartite motif-containing protein 55 (TRIM55)

About Tripartite motif-containing protein 55

Tripartite motif-containing protein 55 (TRIM55) is a protein from Homo sapiens identified by UniProt accession Q9BYV6, 548 residues long. MolForge cross-references it against 0 known binders and 195 disease associations.

Target properties

Protein name	Tripartite motif-containing protein 55
UniProt accession	Q9BYV6
Gene	TRIM55
Organism	Homo sapiens
Length	548 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (195)

Diseases linked to this target (Open Targets).

body mass index · score 0.26
body weight · score 0.18
waist circumference · score 0.16
body height · score 0.16
PHF-tau measurement · score 0.16
hepatocellular carcinoma · score 0.10
neoplasm · score 0.09
gonorrhea · score 0.07
familial atrial fibrillation · score 0.07
Familial short QT syndrome · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BYV6-F1	alphafold	PREDICTED	67.45	—

Amino-acid sequence (548 residues)

MSASLNYKSF SKEQQTMDNL EKQLICPICL EMFTKPVVIL PCQHNLCRKC ASDIFQASNP YLPTRGGTTM ASGGRFRCPS CRHEVVLDRH GVYGLQRNLL VENIIDIYKQ ESTRPEKKSD QPMCEEHEEE RINIYCLNCE VPTCSLCKVF GAHKDCQVAP LTHVFQRQKS ELSDGIAILV GSNDRVQGVI SQLEDTCKTI EECCRKQKQE LCEKFDYLYG ILEERKNEMT QVITRTQEEK LEHVRALIKK YSDHLENVSK LVESGIQFMD EPEMAVFLQN AKTLLKKISE ASKAFQMEKI EHGYENMNHF TVNLNREEKI IREIDFYRED EDEEEEEGGE GEKEGEGEVG GEAVEVEEVE NVQTEFPGED ENPEKASELS QVELQAAPGA LPVSSPEPPP ALPPAADAPV TQGEVVPTGS EQTTESETPV PAAAETADPL FYPSWYKGQT RKATTNPPCT PGSEGLGQIG PPGSEDSNVR KAEVAAAAAS ERAAVSGKET SAPAATSQIG FEAPPLQGQA AAPASGSGAD SEPARHIFSF SWLNSLNE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards