Ankyrin repeat domain-containing protein 60 (ANKRD60)

About Ankyrin repeat domain-containing protein 60

Ankyrin repeat domain-containing protein 60 (ANKRD60) is a protein from Homo sapiens identified by UniProt accession Q9BZ19, 345 residues long. MolForge cross-references it against 0 known binders and 20 disease associations.

Target properties

Protein name	Ankyrin repeat domain-containing protein 60
UniProt accession	Q9BZ19
Gene	ANKRD60
Organism	Homo sapiens
Length	345 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (20)

Diseases linked to this target (Open Targets).

adolescent idiopathic scoliosis · score 0.20
alkaline phosphatase measurement · score 0.09
heel bone mineral density · score 0.07
pancreatic carcinoma · score 0.06
PHF-tau measurement · score 0.06
appendicular lean mass · score 0.05
22q11.2 deletion syndrome · score 0.05
mathematical ability · score 0.04
age-related macular degeneration · score 0.04
wet macular degeneration · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BZ19-F1	alphafold	PREDICTED	72.90	—

Amino-acid sequence (345 residues)

MTRGRAWGMR RAAAGAGGAR AAGPTGGASR LHPNAGRRSG ARAGAQGCGG PRVGSADSRA LPAQPLACAR GRSQRLVCDP KAASALPDLA PDVFVLRVRL EETGEMFRVA NCRGDMTVRE LKEELDLMVG IPFNLQRLQY LDEGVLMDDT TLKFHDVVPG GIISLCIWHH DGWTELVLAA VEGDPSKLSC LGLTEDSFYR TANSEHFEGE KWKHWTSQRA FVALYVASHR GHFDAVQYLL EHGASCLSRS PLGRTPLHVA AAMGRSDCII LLLQHGASIH DRDAKGETPI SIAHRLNHTL SERQMVLLHR IAKSGIRDLN DLVMKNALQR VKSGFRSEKM TMTPH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards