FERM domain-containing protein 8 (FRMD8)

About FERM domain-containing protein 8

FERM domain-containing protein 8 (FRMD8) is a protein from Homo sapiens identified by UniProt accession Q9BZ67, 464 residues long. MolForge cross-references it against 0 known binders and 42 disease associations.

Target properties

Protein name	FERM domain-containing protein 8
UniProt accession	Q9BZ67
Gene	FRMD8
Organism	Homo sapiens
Length	464 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (42)

Diseases linked to this target (Open Targets).

serum alanine aminotransferase measurement · score 0.22
urate measurement · score 0.16
BMI-adjusted hip circumference · score 0.12
genetic disorder · score 0.12
fat body mass · score 0.10
lean body mass · score 0.10
neoplasm · score 0.08
sex hormone-binding globulin measurement · score 0.07
hemoglobin A1 measurement · score 0.07
whole body water mass · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BZ67-F1	alphafold	PREDICTED	79.44	—

Amino-acid sequence (464 residues)

MDGTEGSAGQ PGPAERSHRS SVSSVGARAA DVLVYLADDT VVPLAVENLP SLSAHELHRA VREVLQLPDI ALDVFALWLV SPLLEVQLKP KHQPYKLGRQ WPELLLRFTS APDDDVAMDE PFLQFRRNVF FPKRRELQIH DEEVLRLLYE EAKGNVLAAR YPCDVEDCEA LGALVCRVQL GPYQPGRPAA CDLREKLDSF LPAHLCKRGQ SLFAALRGRG ARAGPGEQGL LNAYRQVQEV SSDGGCEAAL GTHYRAYLLK CHELPFYGCA FFHGEVDKPA QGFLHRGGRK PVSVAISLEG VHVIDSREKH VLLGLRFQEL SWDHTSPEEE EPILWLEFDG DSEGTPVNKL LKIYSKQAEL MSSLIEYCIE LSQAAEPAGP QDSATGSPSD PSSSLAPVQR PKLRRQGSVV SSRIQHLSTI DYVEDGKGIR RVKPKRTTSF FSRQLSLGQG SYTVVQPGDS LEQG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards