About Transmembrane gamma-carboxyglutamic acid protein 4
Transmembrane gamma-carboxyglutamic acid protein 4 (PRRG4) is a protein
from Homo sapiens identified by UniProt accession
Q9BZD6, 226 residues long.
MolForge cross-references it against 0 known binders and
68 disease associations.
Target properties
| Protein name | Transmembrane gamma-carboxyglutamic acid protein 4 |
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| UniProt accession | Q9BZD6 |
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| Gene | PRRG4 |
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| Organism | Homo sapiens |
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| Length | 226 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (68)
Diseases linked to this target (Open Targets).
- platelet count · score 0.33
- platelet crit · score 0.11
- C-reactive protein measurement · score 0.09
- Inguinal hernia · score 0.06
- papillary thyroid carcinoma · score 0.06
- type 2 diabetes mellitus · score 0.04
- sex hormone-binding globulin measurement · score 0.04
- cortical thickness · score 0.04
- FEV/FVC ratio · score 0.04
- cortical surface area measurement · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BZD6-F1 | alphafold | PREDICTED | 66.91 | — |
Amino-acid sequence (226 residues)
MFTLLVLLSQ LPTVTLGFPH CARGPKASKH AGEEVFTSKE EANFFIHRRL LYNRFDLELF TPGNLERECN EELCNYEEAR EIFVDEDKTI AFWQEYSAKG PTTKSDGNRE KIDVMGLLTG LIAAGVFLVI FGLLGYYLCI TKCNRLQHPC SSAVYERGRH TPSIIFRRPE EAALSPLPPS VEDAGLPSYE QAVALTRKHS VSPPPPYPGH TKGFRVFKKS MSLPSH
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