About Tryptase delta
Tryptase delta (TPSD1) is a protein
from Homo sapiens identified by UniProt accession
Q9BZJ3, 242 residues long.
MolForge cross-references it against 0 known binders and
24 disease associations.
Target properties
| Protein name | Tryptase delta |
|---|
| UniProt accession | Q9BZJ3 |
|---|
| Gene | TPSD1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 242 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (24)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.34
- systemic mastocytosis · score 0.19
- bladder exstrophy · score 0.12
- gut microbiome measurement · score 0.07
- eosinophil peroxidase deficiency · score 0.07
- urticaria · score 0.06
- linear and whorled nevoid hypermelanosis · score 0.05
- tryptase beta-2 measurement · score 0.04
- chronic myeloproliferative disorder · score 0.04
- neutropenia, severe congenital, 1, autosomal dominant · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BZJ3-F1 | alphafold | PREDICTED | 85.07 | — |
Amino-acid sequence (242 residues)
MLLLAPQMLS LLLLALPVLA SPAYVAPAPG QALQQTGIVG GQEAPRSKWP WQVSLRVRGP YWMHFCGGSL IHPQWVLTAA HCVEPDIKDL AALRVQLREQ HLYYQDQLLP VSRIIVHPQF YIIQTGADIA LLELEEPVNI SSHIHTVTLP PASETFPPGM PCWVTGWGDV DNNVHLPPPY PLKEVEVPVV ENHLCNAEYH TGLHTGHSFQ IVRDDMLCAG SENHDSCQGD SGGPLVCKVN GT
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