Forkhead box protein P3 (FOXP3)

About Forkhead box protein P3

Forkhead box protein P3 (FOXP3) is a protein from Homo sapiens identified by UniProt accession Q9BZS1, 431 residues long. MolForge cross-references it against 0 known binders and 1,693 disease associations.

Target properties

Protein name	Forkhead box protein P3
UniProt accession	Q9BZS1
Gene	FOXP3
Organism	Homo sapiens
Length	431 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (1693)

Diseases linked to this target (Open Targets).

immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome · score 0.85
type 1 diabetes mellitus · score 0.55
hydrops fetalis · score 0.50
neurodegenerative disease · score 0.45
azoospermia · score 0.43
Neurodevelopmental disorder · score 0.34
Pancytopenia · score 0.34
anemia · score 0.34
multinucleated neurons-anhydramnios-renal dysplasia-cerebellar hypoplasia-hydranencephaly syndrome · score 0.27
genetic disorder · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BZS1-F1	alphafold	PREDICTED	56.73	—

Amino-acid sequence (431 residues)

MPNPRPGKPS APSLALGPSP GASPSWRAAP KASDLLGARG PGGTFQGRDL RGGAHASSSS LNPMPPSQLQ LPTLPLVMVA PSGARLGPLP HLQALLQDRP HFMHQLSTVD AHARTPVLQV HPLESPAMIS LTPPTTATGV FSLKARPGLP PGINVASLEW VSREPALLCT FPNPSAPRKD STLSAVPQSS YPLLANGVCK WPGCEKVFEE PEDFLKHCQA DHLLDEKGRA QCLLQREMVQ SLEQQLVLEK EKLSAMQAHL AGKMALTKAS SVASSDKGSC CIVAAGSQGP VVPAWSGPRE APDSLFAVRR HLWGSHGNST FPEFLHNMDY FKFHNMRPPF TYATLIRWAI LEAPEKQRTL NEIYHWFTRM FAFFRNHPAT WKNAIRHNLS LHKCFVRVES EKGAVWTVDE LEFRKKRSQR PSRCSNPTPG P

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards