About Testis-specific gene 10 protein
Testis-specific gene 10 protein (TSGA10) is a protein
from Homo sapiens identified by UniProt accession
Q9BZW7, 698 residues long.
MolForge cross-references it against 0 known binders and
125 disease associations.
Target properties
| Protein name | Testis-specific gene 10 protein |
|---|
| UniProt accession | Q9BZW7 |
|---|
| Gene | TSGA10 |
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| Organism | Homo sapiens |
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| Length | 698 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (125)
Diseases linked to this target (Open Targets).
- spermatogenic failure 26 · score 0.46
- neurodegenerative disease · score 0.37
- lysosomal storage disease · score 0.25
- multiple sclerosis · score 0.25
- Parkinson disease · score 0.25
- Alzheimer disease · score 0.25
- FEV/FVC ratio · score 0.20
- azoospermia · score 0.09
- male infertility with teratozoospermia due to single gene mutation · score 0.09
- Male infertility with spermatogenesis disorder due to single gene mutation · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BZW7-F1 | alphafold | PREDICTED | 81.65 | — |
Amino-acid sequence (698 residues)
MMRSRSKSPR RPSPTARGAN CDVELLKTTT RDREELKCML EKYERHLAEI QGNVKVLKSE RDKIFLLYEQ AQEEITRLRR EMMKSCKSPK STTAHAILRR VETERDVAFT DLRRMTTERD SLRERLKIAQ ETAFNEKAHL EQRIEELECT VHNLDDERME QMSNMTLMKE TISTVEKEMK SLARKAMDTE SELGRQKAEN NSLRLLYENT EKDLSDTQRH LAKKKYELQL TQEKIMCLDE KIDNFTRQNI AQREEISILG GTLNDLAKEK ECLQACLDKK SENIASLGES LAMKEKTISG MKNIIAEMEQ ASRQCTEALI VCEQDVSRMR RQLDETNDEL AQIARERDIL AHDNDNLQEQ FAKAKQENQA LSKKLNDTHN ELNDIKQKVQ DTNLEVNKLK NILKSEESEN RQMMEQLRKA NEDAENWENK ARQSEADNNT LKLELITAEA EGNRLKEKVD SLNREVEQHL NAERSYKSQI STLHKSVVKM EEELQKVQFE KVSALADLSS TRELCIKLDS SKELLNRQLV AKDQEIEMRE NELDSAHSEI ELLRSQMANE RISMQNLEAL LVANRDKEYQ SQIALQEKES EIQLLKEHLC LAENKMAIQS RDVAQFRNVV TQLEADLDIT KRQLGTERFE RERAVQELRR QNYSSNAYHM SSTMKPNTKC HSPERAHHRS PDRGLDRSLE ENLCYRDF
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