STE20-related kinase adapter protein beta (STRADB)

About STE20-related kinase adapter protein beta

STE20-related kinase adapter protein beta (STRADB) is a protein from Homo sapiens identified by UniProt accession Q9C0K7, 418 residues long. MolForge cross-references it against 0 known binders and 40 disease associations.

Target properties

Protein name	STE20-related kinase adapter protein beta
UniProt accession	Q9C0K7
Gene	STRADB
Organism	Homo sapiens
Length	418 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (40)

Diseases linked to this target (Open Targets).

mean corpuscular hemoglobin concentration · score 0.30
breast adenocarcinoma · score 0.28
lung adenocarcinoma · score 0.26
mean corpuscular hemoglobin · score 0.24
breast carcinoma · score 0.21
body height · score 0.18
serum gamma-glutamyl transferase measurement · score 0.14
clear cell renal carcinoma · score 0.11
triglyceride measurement · score 0.09
reticulocyte measurement · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9C0K7-F1	alphafold	PREDICTED	74.30	—

Amino-acid sequence (418 residues)

MSLLDCFCTS RTQVESLRPE KQSETSIHQY LVDEPTLSWS RPSTRASEVL CSTNVSHYEL QVEIGRGFDN LTSVHLARHT PTGTLVTIKI TNLENCNEER LKALQKAVIL SHFFRHPNIT TYWTVFTVGS WLWVISPFMA YGSASQLLRT YFPEGMSETL IRNILFGAVR GLNYLHQNGC IHRSIKASHI LISGDGLVTL SGLSHLHSLV KHGQRHRAVY DFPQFSTSVQ PWLSPELLRQ DLHGYNVKSD IYSVGITACE LASGQVPFQD MHRTQMLLQK LKGPPYSPLD ISIFPQSESR MKNSQSGVDS GIGESVLVSS GTHTVNSDRL HTPSSKTFSP AFFSLVQLCL QQDPEKRPSA SSLLSHVFFK QMKEESQDSI LSLLPPAYNK PSISLPPVLP WTEPECDFPD EKDSYWEF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards