About Nascent polypeptide-associated complex subunit alpha-2
Nascent polypeptide-associated complex subunit alpha-2 (NACA2) is a protein
from Homo sapiens identified by UniProt accession
Q9H009, 215 residues long.
MolForge cross-references it against 0 known binders and
15 disease associations.
Target properties
| Protein name | Nascent polypeptide-associated complex subunit alpha-2 |
|---|
| UniProt accession | Q9H009 |
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| Gene | NACA2 |
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| Organism | Homo sapiens |
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| Length | 215 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (15)
Diseases linked to this target (Open Targets).
- osteoarthritis, hip · score 0.37
- heel bone mineral density · score 0.34
- body height · score 0.33
- osteoarthritis · score 0.30
- total hip arthroplasty · score 0.30
- beta-amyloid 1-42 measurement · score 0.26
- mean reticulocyte volume · score 0.13
- cancer · score 0.05
- fat body mass · score 0.05
- lean body mass · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9H009-F1 | alphafold | PREDICTED | 72.42 | — |
Amino-acid sequence (215 residues)
MPGEATETVP ATEQELPQSQ AETGSGTASD SGESVPGIEE QDSTQTTTQK AWLVAAAEID EEPVGKAKQS RSEKRARKAM SKLGLLQVTG VTRVTIWKSK NILFVITKLD VYKSPASDAY IVFGEAKIQD LSQQAQLAAA EKFRVQGEAV GNIQENTQTP TVQEESEEEE VDETGVEVKD VKLVMSQANV SRAKAVRALK NNSNDIVNAI MELTV
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