Diphthine methyl ester synthase (DPH5)

About Diphthine methyl ester synthase

Diphthine methyl ester synthase (DPH5) is a protein from Homo sapiens identified by UniProt accession Q9H2P9, 285 residues long. MolForge cross-references it against 0 known binders and 31 disease associations.

Target properties

Protein name	Diphthine methyl ester synthase
UniProt accession	Q9H2P9
Gene	DPH5
Organism	Homo sapiens
Length	285 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (31)

Diseases linked to this target (Open Targets).

neurodevelopmental disorder with short stature, prominent forehead, and feeding difficulties · score 0.63
DPH5-related diphthamide-deficiency syndrome · score 0.42
neurodegenerative disease · score 0.37
monocyte percentage of leukocytes · score 0.32
lymphocyte count · score 0.29
myeloid white cell count · score 0.26
serum alanine aminotransferase measurement · score 0.22
eosinophil count · score 0.22
Neurodevelopmental disorder · score 0.19
reticulocyte count · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9H2P9-F1	alphafold	PREDICTED	92.05	—

Amino-acid sequence (285 residues)

MLYLIGLGLG DAKDITVKGL EVVRRCSRVY LEAYTSVLTV GKEALEEFYG RKLVVADREE VEQEADNILK DADISDVAFL VVGDPFGATT HSDLVLRATK LGIPYRVIHN ASIMNAVGCC GLQLYKFGET VSIVFWTDTW RPESFFDKVK KNRQNGMHTL CLLDIKVKEQ SLENLIKGRK IYEPPRYMSV NQAAQQLLEI VQNQRIRGEE PAVTEETLCV GLARVGADDQ KIAAGTLRQM CTVDLGEPLH SLIITGGSIH PMEMEMLSLF SIPENSSESQ SINGL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards