About Presenilin-associated rhomboid-like protein, mitochondrial
Presenilin-associated rhomboid-like protein, mitochondrial (PARL) is a protein
from Homo sapiens identified by UniProt accession
Q9H300, 379 residues long.
MolForge cross-references it against 0 known binders and
100 disease associations.
Target properties
| Protein name | Presenilin-associated rhomboid-like protein, mitochondrial |
|---|
| UniProt accession | Q9H300 |
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| Gene | PARL |
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| Organism | Homo sapiens |
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| Length | 379 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (100)
Diseases linked to this target (Open Targets).
- age at menopause · score 0.22
- forced expiratory volume · score 0.18
- leprosy · score 0.13
- mean corpuscular hemoglobin concentration · score 0.13
- vital capacity · score 0.11
- Red cell distribution width · score 0.10
- Fuchs endothelial corneal dystrophy · score 0.06
- X-linked endothelial corneal dystrophy · score 0.05
- Familial ocular anterior segment mesenchymal dysgenesis · score 0.05
- granular corneal dystrophy type I · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9H300-F1 | alphafold | PREDICTED | 77.59 | — |
Amino-acid sequence (379 residues)
MAWRGWAQRG WGCGQAWGAS VGGRSCEELT AVLTPPQLLG RRFNFFIQQK CGFRKAPRKV EPRRSDPGTS GEAYKRSALI PPVEETVFYP SPYPIRSLIK PLFFTVGFTG CAFGSAAIWQ YESLKSRVQS YFDGIKADWL DSIRPQKEGD FRKEINKWWN NLSDGQRTVT GIIAANVLVF CLWRVPSLQR TMIRYFTSNP ASKVLCSPML LSTFSHFSLF HMAANMYVLW SFSSSIVNIL GQEQFMAVYL SAGVISNFVS YVGKVATGRY GPSLGASGAI MTVLAAVCTK IPEGRLAIIF LPMFTFTAGN ALKAIIAMDT AGMILGWKFF DHAAHLGGAL FGIWYVTYGH ELIWKNREPL VKIWHEIRTN GPKKGGGSK
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