About Aminopeptidase RNPEPL1
Aminopeptidase RNPEPL1 (RNPEPL1) is a protein
from Homo sapiens identified by UniProt accession
Q9HAU8, 725 residues long.
MolForge cross-references it against 0 known binders and
32 disease associations.
Target properties
| Protein name | Aminopeptidase RNPEPL1 |
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| UniProt accession | Q9HAU8 |
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| Gene | RNPEPL1 |
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| Organism | Homo sapiens |
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| Length | 725 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (32)
Diseases linked to this target (Open Targets).
- mean platelet volume · score 0.34
- platelet count · score 0.30
- erythrocyte count · score 0.29
- mean corpuscular hemoglobin concentration · score 0.28
- mean corpuscular hemoglobin · score 0.27
- blood protein measurement · score 0.27
- reticulocyte count · score 0.27
- hematocrit · score 0.26
- reticulocyte measurement · score 0.26
- platelet component distribution width · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9HAU8-F1 | alphafold | PREDICTED | 86.29 | — |
Amino-acid sequence (725 residues)
MAAQCCCRQA PGAEAAPVRP PPEPPPALDV ASASSAQLFR LRHLQLGLEL RPEARELAGC LVLELCALRP APRALVLDAH PALRLHSAAF RRAPAAAAET PCAFAFSAPG PGPAPPPPLP AFPEAPGSEP ACCPLAFRVD PFTDYGSSLT VTLPPELQAH QPFQVILRYT STDAPAIWWL DPELTYGCAK PFVFTQGHSV CNRSFFPCFD TPAVKCTYSA VVKAPSGVQV LMSATRSAYM EEEGVFHFHM EHPVPAYLVA LVAGDLKPAD IGPRSRVWAE PCLLPTATSK LSGAVEQWLS AAERLYGPYM WGRYDIVFLP PSFPIVAMEN PCLTFIISSI LESDEFLVID VIHEVAHSWF GNAVTNATWE EMWLSEGLAT YAQRRITTET YGAAFTCLET AFRLDALHRQ MKLLGEDSPV SKLQVKLEPG VNPSHLMNLF TYEKGYCFVY YLSQLCGDPQ RFDDFLRAYV EKYKFTSVVA QDLLDSFLSF FPELKEQSVD CRAGLEFERW LNATGPPLAE PDLSQGSSLT RPVEALFQLW TAEPLDQAAA SASAIDISKW RTFQTALFLD RLLDGSPLPQ EVVMSLSKCY SSLLDSMNAE IRIRWLQIVV RNDYYPDLHR VRRFLESQMS RMYTIPLYED LCTGALKSFA LEVFYQTQGR LHPNLRRAIQ QILSQGLGSS TEPASEPSTE LGKAEADTDS DAQALLLGDE APSSAISLRD VNVSA
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