About MAP kinase-interacting serine/threonine-protein kinase 2
MAP kinase-interacting serine/threonine-protein kinase 2 (MKNK2) is a protein
from Homo sapiens identified by UniProt accession
Q9HBH9, 465 residues long.
MolForge cross-references it against 0 known binders and
71 disease associations.
Target properties
| Protein name | MAP kinase-interacting serine/threonine-protein kinase 2 |
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| UniProt accession | Q9HBH9 |
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| Gene | MKNK2 |
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| Organism | Homo sapiens |
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| Length | 465 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (13)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (71)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.54
- Alzheimer disease · score 0.27
- Parkinson disease · score 0.27
- lysosomal storage disease · score 0.27
- multiple sclerosis · score 0.27
- Cleft palate · score 0.26
- cleft lip · score 0.26
- mathematical ability · score 0.22
- non-small cell lung carcinoma · score 0.09
- neoplasm · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9HBH9-F1 | alphafold | PREDICTED | 70.95 | — |
Amino-acid sequence (465 residues)
MVQKKPAELQ GFHRSFKGQN PFELAFSLDQ PDHGDSDFGL QCSARPDMPA SQPIDIPDAK KRGKKKKRGR ATDSFSGRFE DVYQLQEDVL GEGAHARVQT CINLITSQEY AVKIIEKQPG HIRSRVFREV EMLYQCQGHR NVLELIEFFE EEDRFYLVFE KMRGGSILSH IHKRRHFNEL EASVVVQDVA SALDFLHNKG IAHRDLKPEN ILCEHPNQVS PVKICDFDLG SGIKLNGDCS PISTPELLTP CGSAEYMAPE VVEAFSEEAS IYDKRCDLWS LGVILYILLS GYPPFVGRCG SDCGWDRGEA CPACQNMLFE SIQEGKYEFP DKDWAHISCA AKDLISKLLV RDAKQRLSAA QVLQHPWVQG CAPENTLPTP MVLQRNSCAK DLTSFAAEAI AMNRQLAQHD EDLAEEEAAG QGQPVLVRAT SRCLQLSPPS QSKLAQRRQR ASLSSAPVVL VGDHA
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