Serine/threonine-protein kinase Nek6 (NEK6)

About Serine/threonine-protein kinase Nek6

Serine/threonine-protein kinase Nek6 (NEK6) is a protein from Homo sapiens identified by UniProt accession Q9HC98, 313 residues long. MolForge cross-references it against 0 known binders and 127 disease associations.

Target properties

Protein name	Serine/threonine-protein kinase Nek6
UniProt accession	Q9HC98
Gene	NEK6
Organism	Homo sapiens
Length	313 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (3)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (127)

Diseases linked to this target (Open Targets).

lean body mass · score 0.53
monocyte count · score 0.48
body mass index · score 0.46
neutrophil count · score 0.43
hypothyroidism · score 0.42
hair color · score 0.41
fat body mass · score 0.39
monocyte percentage of leukocytes · score 0.39
neurodegenerative disease · score 0.38
Hashimoto's thyroiditis · score 0.36

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9HC98-F1	alphafold	PREDICTED	83.22	—

Amino-acid sequence (313 residues)

MAGQPGHMPH GGSSNNLCHT LGPVHPPDPQ RHPNTLSFRC SLADFQIEKK IGRGQFSEVY KATCLLDRKT VALKKVQIFE MMDAKARQDC VKEIGLLKQL NHPNIIKYLD SFIEDNELNI VLELADAGDL SQMIKYFKKQ KRLIPERTVW KYFVQLCSAV EHMHSRRVMH RDIKPANVFI TATGVVKLGD LGLGRFFSSE TTAAHSLVGT PYYMSPERIH ENGYNFKSDI WSLGCLLYEM AALQSPFYGD KMNLFSLCQK IEQCDYPPLP GEHYSEKLRE LVSMCICPDP HQRPDIGYVH QVAKQMHIWM SST

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards