About Nuclear receptor coactivator 5
Nuclear receptor coactivator 5 (NCOA5) is a protein
from Homo sapiens identified by UniProt accession
Q9HCD5, 579 residues long.
MolForge cross-references it against 0 known binders and
127 disease associations.
Target properties
| Protein name | Nuclear receptor coactivator 5 |
|---|
| UniProt accession | Q9HCD5 |
|---|
| Gene | NCOA5 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 579 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (127)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.36
- neuroticism measurement · score 0.20
- unipolar depression · score 0.16
- erythrocyte count · score 0.15
- wellbeing measurement · score 0.14
- mood disorder · score 0.14
- major depressive disorder · score 0.13
- high density lipoprotein cholesterol measurement · score 0.12
- hepatocellular carcinoma · score 0.10
- MODY · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9HCD5-F1 | alphafold | PREDICTED | 58.88 | — |
Amino-acid sequence (579 residues)
MNTAPSRPSP TRRDPYGFGD SRDSRRDRSP IRGSPRREPR DGRNGRDARD SRDIRDPRDL RDHRHSRDLR DHRDSRSVRD VRDVRDLRDF RDLRDSRDFR DQRDPMYDRY RDMRDSRDPM YRREGSYDRY LRMDDYCRRK DDSYFDRYRD SFDGRGPPGP ESQSRAKERL KREERRREEL YRQYFEEIQR RFDAERPVDC SVIVVNKQTK DYAESVGRKV RDLGMVVDLI FLNTEVSLSQ ALEDVSRGGS PFAIVITQQH QIHRSCTVNI MFGTPQEHRN MPQADAMVLV ARNYERYKNE CREKEREEIA RQAAKMADEA ILQERERGGP EEGVRGGHPP AIQSLINLLA DNRYLTAEET DKIINYLRER KERLMRSSTD SLPGPISRQP LGATSGASLK TQPSSQPLQS GQVLPSATPT PSAPPTSQQE LQAKILSLFN SGTVTANSSS ASPSVAAGNT PNQNFSTAAN SQPQQRSQAS GNQPPSILGQ GGSAQNMGPR PGAPSQGLFG QPSSRLAPAS NMTSQRPVSS TGINFDNPSV QKALDTLIQS GPALSHLVSQ TTAQMGQPQA PMGSYQRHY
Explore Nuclear receptor coactivator 5 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets