Thioredoxin reductase 2, mitochondrial (TXNRD2)

About Thioredoxin reductase 2, mitochondrial

Thioredoxin reductase 2, mitochondrial (TXNRD2) is a protein from Homo sapiens identified by UniProt accession Q9NNW7, 524 residues long. MolForge cross-references it against 0 known binders and 143 disease associations.

Target properties

Protein name	Thioredoxin reductase 2, mitochondrial
UniProt accession	Q9NNW7
Gene	TXNRD2
Organism	Homo sapiens
Length	524 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (143)

Diseases linked to this target (Open Targets).

response to tramadol · score 0.50
familial glucocorticoid deficiency · score 0.47
familial isolated dilated cardiomyopathy · score 0.37
neurofibrillary tangles measurement · score 0.23
intraocular pressure measurement · score 0.22
open-angle glaucoma · score 0.21
dilated cardiomyopathy · score 0.21
Abnormality of the cardiovascular system · score 0.19
breast adenocarcinoma · score 0.18
familial hypertrophic cardiomyopathy · score 0.18

3D Structure

Predicted structure for Q9NNW7 is available from the AlphaFold Protein Structure Database.

Amino-acid sequence (524 residues)

MAAMAVALRG LGGRFRWRTQ AVAGGVRGAA RGAAAGQRDY DLLVVGGGSG GLACAKEAAQ LGRKVAVVDY VEPSPQGTRW GLGGTCVNVG CIPKKLMHQA ALLGGLIQDA PNYGWEVAQP VPHDWRKMAE AVQNHVKSLN WGHRVQLQDR KVKYFNIKAS FVDEHTVCGV AKGGKEILLS ADHIIIATGG RPRYPTHIEG ALEYGITSDD IFWLKESPGK TLVVGASYVA LECAGFLTGI GLDTTIMMRS IPLRGFDQQM SSMVIEHMAS HGTRFLRGCA PSRVRRLPDG QLQVTWEDST TGKEDTGTFD TVLWAIGRVP DTRSLNLEKA GVDTSPDTQK ILVDSREATS VPHIYAIGDV VEGRPELTPI AIMAGRLLVQ RLFGGSSDLM DYDNVPTTVF TPLEYGCVGL SEEEAVARHG QEHVEVYHAH YKPLEFTVAG RDASQCYVKM VCLREPPQLV LGLHFLGPNA GEVTQGFALG IKCGASYAQV MRTVGIHPTC SEEVVKLRIS KRSGLDPTVT GCUG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards