Atypical chemokine receptor 4 (ACKR4)

About Atypical chemokine receptor 4

Atypical chemokine receptor 4 (ACKR4) is a protein from Homo sapiens identified by UniProt accession Q9NPB9, 350 residues long. MolForge cross-references it against 0 known binders and 144 disease associations.

Target properties

Protein name	Atypical chemokine receptor 4
UniProt accession	Q9NPB9
Gene	ACKR4
Organism	Homo sapiens
Length	350 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (144)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.34
low density lipoprotein cholesterol measurement · score 0.21
cortical surface area measurement · score 0.20
apolipoprotein B measurement · score 0.19
leukocyte count · score 0.19
neutrophil count · score 0.19
hemoglobin measurement · score 0.18
total cholesterol measurement · score 0.17
breast adenocarcinoma · score 0.17
hematocrit · score 0.16

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NPB9-F1	alphafold	PREDICTED	81.66	—

Amino-acid sequence (350 residues)

MALEQNQSTD YYYEENEMNG TYDYSQYELI CIKEDVREFA KVFLPVFLTI VFVIGLAGNS MVVAIYAYYK KQRTKTDVYI LNLAVADLLL LFTLPFWAVN AVHGWVLGKI MCKITSALYT LNFVSGMQFL ACISIDRYVA VTKVPSQSGV GKPCWIICFC VWMAAILLSI PQLVFYTVND NARCIPIFPR YLGTSMKALI QMLEICIGFV VPFLIMGVCY FITARTLMKM PNIKISRPLK VLLTVVIVFI VTQLPYNIVK FCRAIDIIYS LITSCNMSKR MDIAIQVTES IALFHSCLNP ILYVFMGASF KNYVMKVAKK YGSWRRQRQS VEEFPFDSEG PTEPTSTFSI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards