About H/ACA ribonucleoprotein complex subunit 3
H/ACA ribonucleoprotein complex subunit 3 (NOP10) is a protein
from Homo sapiens identified by UniProt accession
Q9NPE3, 64 residues long.
MolForge cross-references it against 0 known binders and
34 disease associations.
Target properties
| Protein name | H/ACA ribonucleoprotein complex subunit 3 |
|---|
| UniProt accession | Q9NPE3 |
|---|
| Gene | NOP10 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 64 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (34)
Diseases linked to this target (Open Targets).
- dyskeratosis congenita · score 0.71
- neurodegenerative disease · score 0.51
- pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 9 · score 0.45
- cataracts, hearing impairment, nephrotic syndrome, and enterocolitis 2 · score 0.45
- Hoyeraal-Hreidarsson syndrome · score 0.42
- hereditary neoplastic syndrome · score 0.12
- Inherited cancer-predisposing syndrome · score 0.12
- non-small cell lung carcinoma · score 0.08
- isolated asymptomatic elevation of creatine phosphokinase · score 0.07
- mean platelet volume · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NPE3-F1 | alphafold | PREDICTED | 94.51 | — |
Amino-acid sequence (64 residues)
MFLQYYLNEQ GDRVYTLKKF DPMGQQTCSA HPARFSPDDK YSRHRITIKK RFKVLMTQQP RPVL
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