About E3 ubiquitin-protein ligase TRIM36
E3 ubiquitin-protein ligase TRIM36 (TRIM36) is a protein
from Homo sapiens identified by UniProt accession
Q9NQ86, 728 residues long.
MolForge cross-references it against 0 known binders and
142 disease associations.
Target properties
| Protein name | E3 ubiquitin-protein ligase TRIM36 |
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| UniProt accession | Q9NQ86 |
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| Gene | TRIM36 |
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| Organism | Homo sapiens |
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| Length | 728 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (142)
Diseases linked to this target (Open Targets).
- Isolated anencephaly/exencephaly · score 0.45
- neurodegenerative disease · score 0.40
- anencephaly 1 · score 0.37
- systolic blood pressure · score 0.37
- diastolic blood pressure · score 0.34
- anencephaly · score 0.33
- cortical thickness · score 0.30
- handedness · score 0.30
- hypertension · score 0.29
- clear cell renal carcinoma · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NQ86-F1 | alphafold | PREDICTED | 79.00 | — |
Amino-acid sequence (728 residues)
MSESGEMSEF GYIMELIAKG KVTIKNIERE LICPACKELF THPLILPCQH SICHKCVKEL LLTLDDSFND VGSDNSNQSS PRLRLPSPSM DKIDRINRPG WKRNSLTPRT TVFPCPGCEH DVDLGERGIN GLFRNFTLET IVERYRQAAR AATAIMCDLC KPPPQESTKS CMDCSASYCN ECFKIHHPWG TIKAQHEYVG PTTNFRPKIL MCPEHETERI NMYCELCRRP VCHLCKLGGN HANHRVTTMS SAYKTLKEKL SKDIDYLIGK ESQVKSQISE LNLLMKETEC NGERAKEEAI THFEKLFEVL EERKSSVLKA IDSSKKLRLD KFQTQMEEYQ GLLENNGLVG YAQEVLKETD QSCFVQTAKQ LHLRIQKATE SLKSFRPAAQ TSFEDYVVNT SKQTELLGEL SFFSSGIDVP EINEEQSKVY NNALINWHHP EKDKADSYVL EYRKINRDDE MSWNEIEVCG TSKIIQDLEN SSTYAFRVRA YKGSICSPCS RELILHTPPA PVFSFLFDEK CGYNNEHLLL NLKRDRVESR AGFNLLLAAE RIQVGYYTSL DYIIGDTGIT KGKHFWAFRV EPYSYLVKVG VASSDKLQEW LRSPRDAVSP RYEQDSGHDS GSEDACFDSS QPFTLVTIGM QKFFIPKSPT SSNEPENRVL PMPTSIGIFL DCDKGKVDFY DMDQMKCLYE RQVDCSHTLY PAFALMGSGG IQLEEPITAK YLEYQEDM
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