About Dual specificity tyrosine-phosphorylation-regulated kinase 4
Dual specificity tyrosine-phosphorylation-regulated kinase 4 (DYRK4) is a protein
from Homo sapiens identified by UniProt accession
Q9NR20, 520 residues long.
MolForge cross-references it against 0 known binders and
14 disease associations.
Target properties
| Protein name | Dual specificity tyrosine-phosphorylation-regulated kinase 4 |
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| UniProt accession | Q9NR20 |
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| Gene | DYRK4 |
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| Organism | Homo sapiens |
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| Length | 520 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (14)
Diseases linked to this target (Open Targets).
- drug use measurement · score 0.27
- creatinine measurement · score 0.13
- alkaline phosphatase measurement · score 0.10
- glomerular filtration rate · score 0.07
- body height · score 0.06
- calcium measurement · score 0.06
- phosphorus measurement · score 0.06
- blood phosphate measurement · score 0.04
- neoplasm · score 0.01
- Sepsis · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NR20-F1 | alphafold | PREDICTED | 77.68 | — |
Amino-acid sequence (520 residues)
MPASELKASE IPFHPSIKTQ DPKAEEKSPK KQKVTLTAAE ALKLFKNQLS PYEQSEILGY AELWFLGLEA KKLDTAPEKF SKTSFDDEHG FYLKVLHDHI AYRYEVLETI GKGSFGQVAK CLDHKNNELV ALKIIRNKKR FHQQALMELK ILEALRKKDK DNTYNVVHMK DFFYFRNHFC ITFELLGINL YELMKNNNFQ GFSLSIVRRF TLSVLKCLQM LSVEKIIHCD LKPENIVLYQ KGQASVKVID FGSSCYEHQK VYTYIQSRFY RSPEVILGHP YDVAIDMWSL GCITAELYTG YPLFPGENEV EQLACIMEVL GLPPAGFIQT ASRRQTFFDS KGFPKNITNN RGKKRYPDSK DLTMVLKTYD TSFLDFLRRC LVWEPSLRMT PDQALKHAWI HQSRNLKPQP RPQTLRKSNS FFPSETRKDK VQGCHHSSRK ADEITKETTE KTKDSPTKHV QHSGDQQDCL QHGADTVQLP QLVDAPKKSE AAVGAEVSMT SPGQSKNFSL KNTNVLPPIV
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