About Diablo IAP-binding mitochondrial protein
Diablo IAP-binding mitochondrial protein (DIABLO) is a protein
from Homo sapiens identified by UniProt accession
Q9NR28, 239 residues long.
MolForge cross-references it against 0 known binders and
128 disease associations.
Target properties
| Protein name | Diablo IAP-binding mitochondrial protein |
|---|
| UniProt accession | Q9NR28 |
|---|
| Gene | DIABLO |
|---|
| Organism | Homo sapiens |
|---|
| Length | 239 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (128)
Diseases linked to this target (Open Targets).
- autosomal dominant nonsyndromic hearing loss · score 0.48
- deafness · score 0.43
- ovarian cancer · score 0.25
- breast adenocarcinoma · score 0.25
- head and neck squamous cell carcinoma · score 0.19
- hearing loss · score 0.18
- Hearing impairment · score 0.12
- body height · score 0.11
- neoplasm · score 0.09
- renal cell carcinoma · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NR28-F1 | alphafold | PREDICTED | 82.61 | — |
Amino-acid sequence (239 residues)
MAALKSWLSR SVTSFFRYRQ CLCVPVVANF KKRCFSELIR PWHKTVTIGF GVTLCAVPIA QKSEPHSLSS EALMRRAVSL VTDSTSTFLS QTTYALIEAI TEYTKAVYTL TSLYRQYTSL LGKMNSEEED EVWQVIIGAR AEMTSKHQEY LKLETTWMTA VGLSEMAAEA AYQTGADQAS ITARNHIQLV KLQVEEVHQL SRKAETKLAE AQIEELRQKT QEEGEERAES EQEAYLRED
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