Phospholipid scramblase 3 (PLSCR3)

About Phospholipid scramblase 3

Phospholipid scramblase 3 (PLSCR3) is a protein from Homo sapiens identified by UniProt accession Q9NRY6, 295 residues long. MolForge cross-references it against 0 known binders and 79 disease associations.

Target properties

Protein name	Phospholipid scramblase 3
UniProt accession	Q9NRY6
Gene	PLSCR3
Organism	Homo sapiens
Length	295 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (79)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.44
blood protein measurement · score 0.15
sex hormone-binding globulin measurement · score 0.10
hypertriglyceridemia 2 · score 0.06
obesity due to melanocortin 4 receptor deficiency · score 0.06
cholesterol-ester transfer protein deficiency · score 0.06
MODY · score 0.06
CIDEC-related familial partial lipodystrophy · score 0.05
LIPE-related familial partial lipodystrophy · score 0.05
coronary artery disease, autosomal dominant 2 · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NRY6-F1	alphafold	PREDICTED	70.22	—

Amino-acid sequence (295 residues)

MAGYLPPKGY APSPPPPYPV TPGYPEPALH PGPGQAPVPA QVPAPAPGFA LFPSPGPVAL GSAAPFLPLP GVPSGLEFLV QIDQILIHQK AERVETFLGW ETCNRYELRS GAGQPLGQAA EESNCCARLC CGARRPLRVR LADPGDREVL RLLRPLHCGC SCCPCGLQEM EVQAPPGTTI GHVLQTWHPF LPKFSIQDAD RQTVLRVVGP CWTCGCGTDT NFEVKTRDES RSVGRISKQW GGLVREALTD ADDFGLQFPL DLDVRVKAVL LGATFLIDYM FFEKRGGAGP SAVTS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards