Phospholipid scramblase 2 (PLSCR2)

About Phospholipid scramblase 2

Phospholipid scramblase 2 (PLSCR2) is a protein from Homo sapiens identified by UniProt accession Q9NRY7, 297 residues long. MolForge cross-references it against 0 known binders and 14 disease associations.

Target properties

Protein name	Phospholipid scramblase 2
UniProt accession	Q9NRY7
Gene	PLSCR2
Organism	Homo sapiens
Length	297 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (14)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.32
systemic lupus erythematosus · score 0.11
diabetic eye disease · score 0.10
brain volume measurement · score 0.04
substance abuse · score 0.03
attention deficit hyperactivity disorder · score 0.03
smoking status measurement · score 0.03
antisocial behaviour measurement · score 0.03
gut microbiome measurement · score 0.02
brain measurement · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NRY7-F1	alphafold	PREDICTED	69.91	—

Amino-acid sequence (297 residues)

MRSWNSLFCL NSSRPPGHIV YPKHQAGHTG KQADHLGSQA FYPGRQHDYL VPPAGTAGIP VQNQPGRPEG VPWMPAPPPP LNCPPGLEYL SQIDMILIHQ QIELLEVLFS FESSNMYEIK NSFGQRIYFA AEDTNFCIRN CCGRSRPFTL RITDNVGREV ITLERPLRCN CCCCPCCLQE IEIQAPPGVP VGYVTQTWHP CLTKFTIKNQ KREDVLKISG PCIVCSCIAG VDFEITSLDE QIVVGRISKH WSGFLREAFT DADNFGIQFP RDLDVKMKAV MIGACFLIDY MFFERTR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards