Ras association domain-containing protein 1 (RASSF1)

About Ras association domain-containing protein 1

Ras association domain-containing protein 1 (RASSF1) is a protein from Homo sapiens identified by UniProt accession Q9NS23, 344 residues long. MolForge cross-references it against 0 known binders and 445 disease associations.

Target properties

Protein name	Ras association domain-containing protein 1
UniProt accession	Q9NS23
Gene	RASSF1
Organism	Homo sapiens
Length	344 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (445)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.19
mean platelet volume · score 0.15
neoplasm · score 0.12
hepatocellular carcinoma · score 0.12
non-small cell lung carcinoma · score 0.11
BMI-adjusted waist-hip ratio · score 0.11
cancer · score 0.11
urinary bladder carcinoma · score 0.10
esophageal squamous cell carcinoma · score 0.10
cigarettes per day measurement · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NS23-F1	alphafold	PREDICTED	71.72	—

Amino-acid sequence (344 residues)

MSGEPELIEL RELAPAGRAG KGRTRLERAN ALRIARGTAC NPTRQLVPGR GHRFQPAGPA THTWCDLCGD FIWGVVRKGL QCARLSADCK FTCHYRCRAL VCLDCCGPRD LGWEPAVERD TNVDEPVEWE TPDLSQAEIE QKIKEYNAQI NSNLFMSLNK DGSYTGFIKV QLKLVRPVSV PSSKKPPSLQ DARRGPGRGT SVRRRTSFYL PKDAVKHLHV LSRTRAREVI EALLRKFLVV DDPRKFALFE RAERHGQVYL RKLLDDEQPL RLRLLAGPSD KALSFVLKEN DSGEVNWDAF SMPELHNFLR ILQREEEEHL RQILQKYSYC RQKIQEALHA CPLG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards