Probable G-protein coupled receptor 27 (GPR27)

About Probable G-protein coupled receptor 27

Probable G-protein coupled receptor 27 (GPR27) is a protein from Homo sapiens identified by UniProt accession Q9NS67, 375 residues long. MolForge cross-references it against 0 known binders and 88 disease associations.

Target properties

Protein name	Probable G-protein coupled receptor 27
UniProt accession	Q9NS67
Gene	GPR27
Organism	Homo sapiens
Length	375 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (88)

Diseases linked to this target (Open Targets).

monocyte count · score 0.38
neuroticism measurement · score 0.31
eosinophil count · score 0.25
serum albumin measurement · score 0.21
monocyte percentage of leukocytes · score 0.20
mosaic loss of chromosome Y measurement · score 0.17
apolipoprotein A 1 measurement · score 0.16
eosinophil percentage of leukocytes · score 0.14
hair shape measurement · score 0.14
mitochondrial DNA measurement · score 0.14

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NS67-F1	alphafold	PREDICTED	78.67	—

Amino-acid sequence (375 residues)

MANASEPGGS GGGEAAALGL KLATLSLLLC VSLAGNVLFA LLIVRERSLH RAPYYLLLDL CLADGLRALA CLPAVMLAAR RAAAAAGAPP GALGCKLLAF LAALFCFHAA FLLLGVGVTR YLAIAHHRFY AERLAGWPCA AMLVCAAWAL ALAAAFPPVL DGGGDDEDAP CALEQRPDGA PGALGFLLLL AVVVGATHLV YLRLLFFIHD RRKMRPARLV PAVSHDWTFH GPGATGQAAA NWTAGFGRGP TPPALVGIRP AGPGRGARRL LVLEEFKTEK RLCKMFYAVT LLFLLLWGPY VVASYLRVLV RPGAVPQAYL TASVWLTFAQ AGINPVVCFL FNRELRDCFR AQFPCCQSPR TTQATHPCDL KGIGL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards