About Cysteinyl leukotriene receptor 2
Cysteinyl leukotriene receptor 2 (CYSLTR2) is a protein
from Homo sapiens identified by UniProt accession
Q9NS75, 346 residues long.
MolForge cross-references it against 0 known binders and
190 disease associations.
Target properties
| Protein name | Cysteinyl leukotriene receptor 2 |
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| UniProt accession | Q9NS75 |
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| Gene | CYSLTR2 |
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| Organism | Homo sapiens |
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| Length | 346 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (4)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (190)
Diseases linked to this target (Open Targets).
- Uveal Melanoma · score 0.26
- cervical squamous cell carcinoma · score 0.26
- glioblastoma multiforme · score 0.25
- breast adenocarcinoma · score 0.24
- thyroid gland adenocarcinoma · score 0.23
- prostate adenocarcinoma · score 0.21
- synovium disorder · score 0.20
- synovial bursa disorder · score 0.20
- Tendinopathy · score 0.20
- melanoma · score 0.20
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NS75-F1 | alphafold | PREDICTED | 84.51 | — |
Amino-acid sequence (346 residues)
MERKFMSLQP SISVSEMEPN GTFSNNNSRN CTIENFKREF FPIVYLIIFF WGVLGNGLSI YVFLQPYKKS TSVNVFMLNL AISDLLFIST LPFRADYYLR GSNWIFGDLA CRIMSYSLYV NMYSSIYFLT VLSVVRFLAM VHPFRLLHVT SIRSAWILCG IIWILIMASS IMLLDSGSEQ NGSVTSCLEL NLYKIAKLQT MNYIALVVGC LLPFFTLSIC YLLIIRVLLK VEVPESGLRV SHRKALTTII ITLIIFFLCF LPYHTLRTVH LTTWKVGLCK DRLHKALVIT LALAAANACF NPLLYYFAGE NFKDRLKSAL RKGHPQKAKT KCVFPVSVWL RKETRV
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