Zinc finger protein 275 (ZNF275)

About Zinc finger protein 275

Zinc finger protein 275 (ZNF275) is a protein from Homo sapiens identified by UniProt accession Q9NSD4, 429 residues long. MolForge cross-references it against 0 known binders and 27 disease associations.

Target properties

Protein name	Zinc finger protein 275
UniProt accession	Q9NSD4
Gene	ZNF275
Organism	Homo sapiens
Length	429 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (27)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.37
benign neoplasm of adrenal gland · score 0.31
hemoglobin D disease · score 0.05
dominant beta-thalassemia · score 0.04
delta-beta-thalassemia · score 0.04
hemoglobin E disease · score 0.04
hemoglobin C-beta-thalassemia syndrome · score 0.04
Alpha-thalassemia - myelodysplastic syndrome · score 0.04
alpha-thalassemia-myelodysplastic syndrome · score 0.04
hemoglobin E-beta-thalassemia syndrome · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NSD4-F1	alphafold	PREDICTED	72.15	—

Amino-acid sequence (429 residues)

MMSHPCVSLL GVPVLNPALV PHLAQGQVLL VSDPSPNTDP AKYSESTSAT RHQMKGEDAQ PQEMASTSFP RASGPSPEFR QHGDSDGKRG SPQNLPIEHH FACKECGDTF RLKVLLVQHQ RVHSEEKGWE CGDCGKVFRG VAEFNEHRKS HVAAEPQPGP SRALENAAEK REQMEREAKP FECEECGKRF KKNAGLSQHL RVHSREKPFD CEECGRSFKV NTHLFRHQKL HTSEKPFACK ACSRDFLDRQ ELLKHQRMHT GHLPFDCDDC GKSFRGVNGL AEHQRIHSGA KPYGCPHCGK LFRRSSELTK HRRIHTGEKP YACGQCGKAF RQSSSLLEHA RIHSGERPYA CGECGKAFRG PSDLIKHRRI HSGLKPYECD KCGKAFRRSS GLSRHRRIHS GARRCECSQC GRVFKRRSAL QKHQPTHHE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards