About FIGNL1-interacting regulator of recombination and mitosis
FIGNL1-interacting regulator of recombination and mitosis (FIRRM) is a protein
from Homo sapiens identified by UniProt accession
Q9NSG2, 853 residues long.
MolForge cross-references it against 0 known binders and
69 disease associations.
Target properties
| Protein name | FIGNL1-interacting regulator of recombination and mitosis |
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| UniProt accession | Q9NSG2 |
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| Gene | FIRRM |
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| Organism | Homo sapiens |
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| Length | 853 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (69)
Diseases linked to this target (Open Targets).
- total blood protein measurement · score 0.23
- L-Selectin measurement · score 0.21
- blood protein measurement · score 0.21
- acne · score 0.20
- leukocyte count · score 0.16
- monocyte count · score 0.16
- eosinophil count · score 0.16
- monocyte percentage of leukocytes · score 0.15
- eosinophil percentage of leukocytes · score 0.14
- age at menopause · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NSG2-F1 | alphafold | PREDICTED | 86.73 | — |
Amino-acid sequence (853 residues)
MFLPHMNHLT LEQTFFSQVL PKTVKLFDDM MYELTSQARG LSSQNLEIQT TLRNILQTMV QLLGALTGCV QHICATQESI ILENIQSLPS SVLHIIKSTF VHCKNSESVY SGCLHLVSDL LQALFKEAYS LQKQLMELLD MVCMDPLVDD NDDILNMVIV IHSLLDICSV ISSMDHAFHA NTWKFIIKQS LKHQSIIKSQ LKHKDIITSL CEDILFSFHS CLQLAEQMTQ SDAQDNADYR LFQKTLKLCR FFANSLLHYA KEFLPFLSDS CCTLHQLYLQ IHSKFPPSLY ATRISKAHQE EIAGAFLVTL DPLISQLLTF QPFMQVVLDS KLDLPCELQF PQCLLLVVVM DKLPSQPKEV QTLWCTDSQV SETTTRISLL KAVFYSFEQC SGELSLPVHL QGLKSKGKAE VAVTLYQHVC VHLCTFITSF HPSLFAELDA ALLNAVLSAN MITSLLAMDA WCFLARYGTA ELCAHHVTIV AHLIKSCPGE CYQLINLSIL LKRLFFFMAP PHQLEFIQKF SPKEAENLPL WQHISFQALP PELREQTVHE VTTVGTAECR KWLSRSRTLG ELESLNTVLS ALLAVCNSAG EALDTGKQTA IIEVVSQLWA FLNIKQVADQ PYVQQTFSLL LPLLGFFIQT LDPKLILQAV TLQTSLLKLE LPDYVRLAML DFVSSLGKLF IPEAIQDRIL PNLSCMFALL LADRSWLLEQ HTLEAFTQFA EGTNHEEIVP QCLSSEETKN KVVSFLEKTG FVDETEAAKV ERVKQEKGIF WEPFANVTVE EAKRSSLQPY AKRARQEFPW EEEYRSALHT IAGALEATES LLQKGPAPAW LSMEMEALQE RMDKLKRYIH TLG
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