About PAK4-inhibitor INKA2
PAK4-inhibitor INKA2 (INKA2) is a protein
from Homo sapiens identified by UniProt accession
Q9NTI7, 297 residues long.
MolForge cross-references it against 0 known binders and
55 disease associations.
Target properties
| Protein name | PAK4-inhibitor INKA2 |
|---|
| UniProt accession | Q9NTI7 |
|---|
| Gene | INKA2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 297 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (55)
Diseases linked to this target (Open Targets).
- body mass index · score 0.39
- waist-hip ratio · score 0.35
- blood protein measurement · score 0.29
- brain measurement · score 0.23
- mathematical ability · score 0.22
- type 2 diabetes mellitus · score 0.22
- self reported educational attainment · score 0.22
- multisite chronic pain · score 0.21
- body height · score 0.20
- lymphocyte count · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NTI7-F1 | alphafold | PREDICTED | 61.50 | — |
Amino-acid sequence (297 residues)
MTMESREMDC YLRRLKQELM SMKEVGDGLQ DQMNCMMGAL QELKLLQVQT ALEQLEISGG GPVPGSPEGP RTQCEHPCWE GGRGPARPTV CSPSSQPSLG SSTKFPSHRS VCGRDLAPLP RTQPHQSCAQ QGPERVEPDD WTSTLMSRGR NRQPLVLGDN VFADLVGNWL DLPELEKGGE KGETGGAREP KGEKGQPQEL GRRFALTANI FKKFLRSVRP DRDRLLKEKP GWVTPMVPES RTGRSQKVKK RSLSKGSGHF PFPGTGEHRR GENPPTSCPK ALEHSPSGFD INTAVWV
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