About Semaphorin-4G
Semaphorin-4G (SEMA4G) is a protein
from Homo sapiens identified by UniProt accession
Q9NTN9, 838 residues long.
MolForge cross-references it against 0 known binders and
47 disease associations.
Target properties
| Protein name | Semaphorin-4G |
|---|
| UniProt accession | Q9NTN9 |
|---|
| Gene | SEMA4G |
|---|
| Organism | Homo sapiens |
|---|
| Length | 838 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (47)
Diseases linked to this target (Open Targets).
- serum gamma-glutamyl transferase measurement · score 0.39
- testosterone measurement · score 0.24
- lean body mass · score 0.15
- age at first facial hair · score 0.12
- body mass index · score 0.12
- smoking status measurement · score 0.11
- puberty onset measurement · score 0.11
- body weight · score 0.08
- forced expiratory volume · score 0.08
- blood urea nitrogen measurement · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NTN9-F1 | alphafold | PREDICTED | 79.76 | — |
Amino-acid sequence (838 residues)
MWGRLWPLLL SILTATAVPG PSLRRPSREL DATPRMTIPY EELSGTRHFK GQAQNYSTLL LEEASARLLV GARGALFSLS ANDIGDGAHK EIHWEASPEM QSKCHQKGKN NQTECFNHVR FLQRLNSTHL YACGTHAFQP LCAAIDAEAF TLPTSFEEGK EKCPYDPARG FTGLIIDGGL YTATRYEFRS IPDIRRSRHP HSLRTEETPM HWLNDAEFVF SVLVRESKAS AVGDDDKVYY FFTERATEEG SGSFTQSRSS HRVARVARVC KGDLGGKKIL QKKWTSFLKA RLICHIPLYE TLRGVCSLDA ETSSRTHFYA AFTLSTQWKT LEASAICRYD LAEIQAVFAG PYMEYQDGSR RWGRYEGGVP EPRPGSCITD SLRSQGYNSS QDLPSLVLDF VKLHPLMARP VVPTRGRPLL LKRNIRYTHL TGTPVTTPAG PTYDLLFLGT ADGWIHKAVV LGSGMHIIEE TQVFRESQSV ENLVISLLQH SLYVGAPSGV IQLPLSSCSR YRSCYDCILA RDPYCGWDPG THACAAATTI ANRTALIQDI ERGNRGCESS RDTGPPPPLK TRSVLRGDDV LLPCDQPSNL ARALWLLNGS MGLSDGQGGY RVGVDGLLVT DAQPEHSGNY GCYAEENGLR TLLASYSLTV RPATPAPAPK APATPGAQLA PDVRLLYVLA IAALGGLCLI LASSLLYVAC LREGRRGRRR KYSLGRASRA GGSAVQLQTV SGQCPGEEDE GDDEGAGGLE GSCLQIIPGE GAPAPPPPPP PPPPAELTNG LVALPSRLRR MNGNSYVLLR QSNNGVPAGP CSFAEELSRI LEKRKHTQLV EQLDESSV
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