p53 and DNA damage-regulated protein 1 (PDRG1)

About p53 and DNA damage-regulated protein 1

p53 and DNA damage-regulated protein 1 (PDRG1) is a protein from Homo sapiens identified by UniProt accession Q9NUG6, 133 residues long. MolForge cross-references it against 0 known binders and 43 disease associations.

Target properties

Protein name	p53 and DNA damage-regulated protein 1
UniProt accession	Q9NUG6
Gene	PDRG1
Organism	Homo sapiens
Length	133 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (43)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.15
glioblastoma multiforme · score 0.08
urinary bladder carcinoma · score 0.07
neoplasm · score 0.06
cancer · score 0.06
metabolite measurement · score 0.05
osteosarcoma · score 0.05
hepatocellular carcinoma · score 0.04
drug use measurement · score 0.03
monocyte percentage of leukocytes · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NUG6-F1	alphafold	PREDICTED	91.89	—

Amino-acid sequence (133 residues)

MLSPEAERVL RYLVEVEELA EEVLADKRQI VDLDTKRNQN REGLRALQKD LSLSEDVMVC FGNMFIKMPH PETKEMIEKD QDHLDKEIEK LRKQLKVKVN RLFEAQGKPE LKGFNLNPLN QDELKALKVI LKG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards