About Lysosomal cobalamin transport escort protein LMBD1
Lysosomal cobalamin transport escort protein LMBD1 (LMBRD1) is a protein
from Homo sapiens identified by UniProt accession
Q9NUN5, 540 residues long.
MolForge cross-references it against 0 known binders and
75 disease associations.
Target properties
| Protein name | Lysosomal cobalamin transport escort protein LMBD1 |
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| UniProt accession | Q9NUN5 |
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| Gene | LMBRD1 |
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| Organism | Homo sapiens |
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| Length | 540 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (75)
Diseases linked to this target (Open Targets).
- methylmalonic aciduria and homocystinuria type cblF · score 0.76
- Methylmalonic acidemia with homocystinuria type cblF · score 0.65
- Methylmalonic acidemia with homocystinuria · score 0.53
- methylmalonic aciduria and homocystinuria type cblC · score 0.44
- Methylmalonic acidemia with homocystinuria, type cblC · score 0.44
- genetic disorder · score 0.41
- homocystinuria · score 0.37
- Vitamin B12-responsive methylmalonic acidemia type cblB · score 0.37
- liver fat measurement · score 0.22
- disorders of vitamin D metabolism · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NUN5-F1 | alphafold | PREDICTED | 83.84 | — |
Amino-acid sequence (540 residues)
MATSGAASAE LVIGWCIFGL LLLAILAFCW IYVRKYQSRR ESEVVSTITA IFSLAIALIT SALLPVDIFL VSYMKNQNGT FKDWANANVS RQIEDTVLYG YYTLYSVILF CVFFWIPFVY FYYEEKDDDD TSKCTQIKTA LKYTLGFVVI CALLLLVGAF VPLNVPNNKN STEWEKVKSL FEELGSSHGL AALSFSISSL TLIGMLAAIT YTAYGMSALP LNLIKGTRSA AYERLENTED IEEVEQHIQT IKSKSKDGRP LPARDKRALK QFEERLRTLK KRERHLEFIE NSWWTKFCGA LRPLKIVWGI FFILVALLFV ISLFLSNLDK ALHSAGIDSG FIIFGANLSN PLNMLLPLLQ TVFPLDYILI TIIIMYFIFT SMAGIRNIGI WFFWIRLYKI RRGRTRPQAL LFLCMILLLI VLHTSYMIYS LAPQYVMYGS QNYLIETNIT SDNHKGNSTL SVPKRCDADA PEDQCTVTRT YLFLHKFWFF SAAYYFGNWA FLGVFLIGLI VSCCKGKKSV IEGVDEDSDI SDDEPSVYSA
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