ATP-dependent RNA helicase DDX19A (DDX19A)

About ATP-dependent RNA helicase DDX19A

ATP-dependent RNA helicase DDX19A (DDX19A) is a protein from Homo sapiens identified by UniProt accession Q9NUU7, 478 residues long. MolForge cross-references it against 0 known binders and 28 disease associations.

Target properties

Protein name	ATP-dependent RNA helicase DDX19A
UniProt accession	Q9NUU7
Gene	DDX19A
Organism	Homo sapiens
Length	478 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (28)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.43
Parkinson disease · score 0.24
multiple sclerosis · score 0.24
Alzheimer disease · score 0.24
lysosomal storage disease · score 0.24
haptoglobin measurement · score 0.20
gastric carcinoma · score 0.15
body height · score 0.09
body mass index · score 0.08
blood protein measurement · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NUU7-F1	alphafold	PREDICTED	80.69	—

Amino-acid sequence (478 residues)

MATDSWALAV DEQEAAVKSM TNLQIKEEKV KADTNGIIKT STTAEKTDEE EKEDRAAQSL LNKLIRSNLV DNTNQVEVLQ RDPNSPLYSV KSFEELRLKP QLLQGVYAMG FNRPSKIQEN ALPMMLAEPP QNLIAQSQSG TGKTAAFVLA MLSRVEPSDR YPQCLCLSPT YELALQTGKV IEQMGKFYPE LKLAYAVRGN KLERGQKISE QIVIGTPGTV LDWCSKLKFI DPKKIKVFVL DEADVMIATQ GHQDQSIRIQ RMLPRNCQML LFSATFEDSV WKFAQKVVPD PNVIKLKREE ETLDTIKQYY VLCSSRDEKF QALCNLYGAI TIAQAMIFCH TRKTASWLAA ELSKEGHQVA LLSGEMMVEQ RAAVIERFRE GKEKVLVTTN VCARGIDVEQ VSVVINFDLP VDKDGNPDNE TYLHRIGRTG RFGKRGLAVN MVDSKHSMNI LNRIQEHFNK KIERLDTDDL DEIEKIAN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards