Transmembrane protein 100 (TMEM100)

About Transmembrane protein 100

Transmembrane protein 100 (TMEM100) is a protein from Homo sapiens identified by UniProt accession Q9NV29, 134 residues long. MolForge cross-references it against 0 known binders and 124 disease associations.

Target properties

Protein name	Transmembrane protein 100
UniProt accession	Q9NV29
Gene	TMEM100
Organism	Homo sapiens
Length	134 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (124)

Diseases linked to this target (Open Targets).

BMI-adjusted waist-hip ratio · score 0.24
waist-hip ratio · score 0.17
body height · score 0.12
lung adenocarcinoma · score 0.08
hepatocellular carcinoma · score 0.08
esophageal squamous cell carcinoma · score 0.07
hip circumference · score 0.07
non-small cell lung carcinoma · score 0.06
neoplasm · score 0.06
familial thoracic aortic aneurysm and aortic dissection · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NV29-F1	alphafold	PREDICTED	66.43	—

Amino-acid sequence (134 residues)

MTEEPIKEIL GAPKAHMAAT MEKSPKSEVV ITTVPLVSEI QLMAATGGTE LSCYRCIIPF AVVVFIAGIV VTAVAYSFNS HGSIISIFGL VVLSSGLFLL ASSALCWKVR QRSKKAKRRE SQTALVANQR SLFA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards