About U3 small nucleolar ribonucleoprotein protein IMP3
U3 small nucleolar ribonucleoprotein protein IMP3 (IMP3) is a protein
from Homo sapiens identified by UniProt accession
Q9NV31, 184 residues long.
MolForge cross-references it against 0 known binders and
23 disease associations.
Target properties
| Protein name | U3 small nucleolar ribonucleoprotein protein IMP3 |
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| UniProt accession | Q9NV31 |
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| Gene | IMP3 |
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| Organism | Homo sapiens |
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| Length | 184 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (23)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.48
- multiple sclerosis · score 0.46
- lysosomal storage disease · score 0.46
- Parkinson disease · score 0.46
- Alzheimer disease · score 0.46
- appendicular lean mass · score 0.06
- platelet count · score 0.05
- fat body mass · score 0.05
- testosterone measurement · score 0.05
- type 2 diabetes mellitus · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NV31-F1 | alphafold | PREDICTED | 90.75 | — |
Amino-acid sequence (184 residues)
MVRKLKFHEQ KLLKQVDFLN WEVTDHNLHE LRVLRRYRLQ RREDYTRYNQ LSRAVRELAR RLRDLPERDQ FRVRASAALL DKLYALGLVP TRGSLELCDF VTASSFCRRR LPTVLLKLRM AQHLQAAVAF VEQGHVRVGP DVVTDPAFLV TRSMEDFVTW VDSSKIKRHV LEYNEERDDF DLEA
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