About Exocyst complex component 1
Exocyst complex component 1 (EXOC1) is a protein
from Homo sapiens identified by UniProt accession
Q9NV70, 894 residues long.
MolForge cross-references it against 0 known binders and
31 disease associations.
Target properties
| Protein name | Exocyst complex component 1 |
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| UniProt accession | Q9NV70 |
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| Gene | EXOC1 |
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| Organism | Homo sapiens |
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| Length | 894 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (31)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.48
- cervical carcinoma · score 0.20
- endometrial cancer · score 0.18
- squamous cell lung carcinoma · score 0.12
- head and neck squamous cell carcinoma · score 0.09
- albuminuria · score 0.06
- response to selective serotonin reuptake inhibitor · score 0.02
- high density lipoprotein cholesterol measurement · score 0.02
- adolescent idiopathic scoliosis · score 0.02
- cancer · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NV70-F1 | alphafold | PREDICTED | 79.84 | — |
Amino-acid sequence (894 residues)
MTAIKHALQR DIFTPNDERL LSIVNVCKAG KKKKNCFLCA TVTTERPVQV KVVKVKKSDK GDFYKRQIAW ALRDLAVVDA KDAIKENPEF DLHFEKIYKW VASSTAEKNA FISCIWKLNQ RYLRKKIDFV NVSSQLLEES VPSGENQSVT GGDEEVVDEY QELNAREEQD IEIMMEGCEY AISNAEAFAE KLSRELQVLD GANIQSIMAS EKQVNILMKL LDEALKEVDQ IELKLSSYEE MLQSVKEQMD QISESNHLIH LSNTNNVKLL SEIEFLVNHM DLAKGHIKAL QEGDLASSRG IEACTNAADA LLQCMNVALR PGHDLLLAVK QQQQRFSDLR ELFARRLASH LNNVFVQQGH DQSSTLAQHS VELTLPNHHP FHRDLLRYAK LMEWLKSTDY GKYEGLTKNY MDYLSRLYER EIKDFFEVAK IKMTGTTKES KKFATLPRKE SAVKQETESL HGSSGKLTGS TSSLNKLSVQ SSGNRRSQSS SLLDMGNMSA SDLDVADRTK FDKIFEQVLS ELEPLCLAEQ DFISKFFKLQ QHQSMPGTMA EAEDLDGGTL SRQHNCGTPL PVSSEKDMIR QMMIKIFRCI EPELNNLIAL GDKIDSFNSL YMLVKMSHHV WTAQNVDPAS FLSTTLGNVL VTVKRNFDKC ISNQIRQMEE VKISKKSKVG ILPFVAEFEE FAGLAESIFK NAERRGDLDK AYTKLIRGVF VNVEKVANES QKTPRDVVMM ENFHHIFATL SRLKISCLEA EKKEAKQKYT DHLQSYVIYS LGQPLEKLNH FFEGVEARVA QGIREEEVSY QLAFNKQELR KVIKEYPGKE VKKGLDNLYK KVDKHLCEEE NLLQVVWHSM QDEFIRQYKH FEGLIARCYP GSGVTMEFTI QDILDYCSSI AQSH
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