E3 ubiquitin-protein ligase FANCL (FANCL)

About E3 ubiquitin-protein ligase FANCL

E3 ubiquitin-protein ligase FANCL (FANCL) is a protein from Homo sapiens identified by UniProt accession Q9NW38, 375 residues long. MolForge cross-references it against 0 known binders and 348 disease associations.

Target properties

Protein name	E3 ubiquitin-protein ligase FANCL
UniProt accession	Q9NW38
Gene	FANCL
Organism	Homo sapiens
Length	375 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (348)

Diseases linked to this target (Open Targets).

Fanconi anemia complementation group L · score 0.79
Fanconi anemia · score 0.78
myelodysplastic syndrome · score 0.46
acute myeloid leukemia · score 0.46
Fanconi anemia complementation group A · score 0.45
BMI-adjusted waist circumference · score 0.40
BMI-adjusted waist-hip ratio · score 0.39
neurodegenerative disease · score 0.37
head and neck malignant neoplasia · score 0.37
Abnormal radial ray morphology · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NW38-F1	alphafold	PREDICTED	91.34	—

Amino-acid sequence (375 residues)

MAVTEASLLR QCPLLLPQNR SKTVYEGFIS AQGRDFHLRI VLPEDLQLKN ARLLCSWQLR TILSGYHRIV QQRMQHSPDL MSFMMELKML LEVALKNRQE LYALPPPPQF YSSLIEEIGT LGWDKLVYAD TCFSTIKLKA EDASGREHLI TLKLKAKYPA ESPDYFVDFP VPFCASWTPQ SSLISIYSQF LAAIESLKAF WDVMDEIDEK TWVLEPEKPP RSATARRIAL GNNVSINIEV DPRHPTMLPE CFFLGADHVV KPLGIKLSRN IHLWDPENSV LQNLKDVLEI DFPARAILEK SDFTMDCGIC YAYQLDGTIP DQVCDNSQCG QPFHQICLYE WLRGLLTSRQ SFNIIFGECP YCSKPITLKM SGRKH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards