G patch domain-containing protein 2 (GPATCH2)

About G patch domain-containing protein 2

G patch domain-containing protein 2 (GPATCH2) is a protein from Homo sapiens identified by UniProt accession Q9NW75, 528 residues long. MolForge cross-references it against 0 known binders and 47 disease associations.

Target properties

Protein name	G patch domain-containing protein 2
UniProt accession	Q9NW75
Gene	GPATCH2
Organism	Homo sapiens
Length	528 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (47)

Diseases linked to this target (Open Targets).

diastolic blood pressure · score 0.34
lean body mass · score 0.28
neurodegenerative disease · score 0.27
resting heart rate · score 0.24
hypertension · score 0.23
fat body mass · score 0.23
body weight · score 0.19
body height · score 0.19
whole body water mass · score 0.18
base metabolic rate measurement · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NW75-F1	alphafold	PREDICTED	55.70	—

Amino-acid sequence (528 residues)

MFGAAGRQPI GAPAAGNSWH FSRTMEELVH DLVSALEESS EQARGGFAET GDHSRSISCP LKRQARKRRG RKRRSYNVHH PWETGHCLSE GSDSSLEEPS KDYRENHNNN KKDHSDSDDQ MLVAKRRPSS NLNNNVRGKR PLWHESDFAV DNVGNRTLRR RRKVKRMAVD LPQDISNKRT MTQPPEGCRD QDMDSDRAYQ YQEFTKNKVK KRKLKIIRQG PKIQDEGVVL ESEETNQTNK DKMECEEQKV SDELMSESDS SSLSSTDAGL FTNDEGRQGD DEQSDWFYEK ESGGACGITG VVPWWEKEDP TELDKNVPDP VFESILTGSF PLMSHPSRRG FQARLSRLHG MSSKNIKKSG GTPTSMVPIP GPVGNKRMVH FSPDSHHHDH WFSPGARTEH DQHQLLRDNR AERGHKKNCS VRTASRQTSM HLGSLCTGDI KRRRKAAPLP GPTTAGFVGE NAQPILENNI GNRMLQNMGW TPGSGLGRDG KGISEPIQAM QRPKGLGLGF PLPKSTSATT TPNAGKSA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards